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The free energy landscape in translational science: how can somatic mutations result in constitutive oncogenic activation?

The free energy landscape theory has transformed the field of protein folding. The significance of perceiving function in terms of conformational heterogeneity is gradually shifting the interest in the community from folding to function. From the free energy landscape standpoint the principles are u...

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Detalles Bibliográficos
Publicado en:Phys Chem Chem Phys
Main Authors: Tsai, Chung-Jung, Nussinov, Ruth
Formato: Artigo
Idioma:Inglês
Publicado: 2014
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7667491/
https://ncbi.nlm.nih.gov/pubmed/24445437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3cp54253j
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