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Protein–protein interaction networks: how can a hub protein bind so many different partners?

How can a single hub protein bind so many different partners? Numerous studies have sought differences between hubs and non-hubs to explain what makes a protein a hub and how a shared hub-binding site can be promiscuous, yet at the same time be specific. Here, we suggest that the problem is largely...

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Publicat a:Trends Biochem Sci
Autors principals: Tsai, Chung-Jung, Ma, Buyong, Nussinov, Ruth
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7292551/
https://ncbi.nlm.nih.gov/pubmed/19837592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tibs.2009.07.007
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