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How do transcription factors select specific binding sites in the genome?

How does a transcription factor select a specific DNA response element given the presence of degenerate sequences? To date, this question has largely been viewed from the standpoint of DNA sequence variability and transcription factor binding affinity under steady-state conditions. Here we propose t...

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Detalhes bibliográficos
Publicado no:Nat Struct Mol Biol
Main Authors: Pan, Yongping, Tsai, Chung-Jung, Ma, Buyong, Nussinov, Ruth
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6416780/
https://ncbi.nlm.nih.gov/pubmed/19888307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb1109-1118
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