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How do transcription factors select specific binding sites in the genome?

How does a transcription factor select a specific DNA response element given the presence of degenerate sequences? To date, this question has largely been viewed from the standpoint of DNA sequence variability and transcription factor binding affinity under steady-state conditions. Here we propose t...

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Veröffentlicht in:Nat Struct Mol Biol
Hauptverfasser: Pan, Yongping, Tsai, Chung-Jung, Ma, Buyong, Nussinov, Ruth
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6416780/
https://ncbi.nlm.nih.gov/pubmed/19888307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb1109-1118
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