Digitoxigenin presents an effective and selective antileishmanial action against Leishmania infantum and is a potential therapeutic agent for visceral leishmaniasis

Treatment for visceral leishmaniasis (VL) is hampered mainly by drug toxicity, their high cost, and parasite resistance. Drug development is a long and pricey process, and therefore, drug repositioning may be an alternative worth pursuing. Cardenolides are used to treat cardiac diseases, especially...

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Bibliografiske detaljer
Udgivet i:Parasitol Res
Main Authors: Freitas, Camila S., Oliveira-da-Silva, João A., Lage, Daniela P., Costa, Rafaella R., Mendonça, Débora V. C., Martins, Vívian T., Reis, Thiago A. R., Antinarelli, Luciana M. R., Machado, Amanda S., Tavares, Grasiele S. V., Ramos, Fernanda F., Coelho, Vinicio T. S., Brito, Rory C. F., Ludolf, Fernanda, Chávez-Fumagalli, Miguel A., Roatt, Bruno M., Ramos, Gabriela S., Munkert, Jennifer, Ottoni, Flaviano M., Campana, Priscilla R. V., Humbert, Maria V., Coimbra, Elaine S., Braga, Fernão C., Pádua, Rodrigo M., Coelho, Eduardo A. F.
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2020
Fag:
Treatment and Prophylaxis - Original Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7667010/
https://ncbi.nlm.nih.gov/pubmed/33191446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00436-020-06971-2
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