Identification of Chalcone Derivatives as Inhibitors of Leishmania infantum Arginase and Promising Antileishmanial Agents

Arginase catalyzes the hydrolysis of l-arginine into l-ornithine and urea, acting as a key enzyme in the biosynthesis of polyamines. Leishmania growth and survival is dependent on polyamine biosynthesis; therefore, inhibition of Leishmania arginase may be a promising therapeutic strategy. Here, we e...

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Pubblicato in:Front Chem
Autori principali: Garcia, Andreza R., Oliveira, Danielle M. P., Jesus, Jessica B., Souza, Alessandra M. T., Sodero, Ana Carolina R., Vermelho, Alane B., Leal, Ivana C. R., Souza, Rodrigo Octavio M. A., Miranda, Leandro S. M., Pinheiro, Anderson S., Rodrigues, Igor A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2021
Soggetti:
Chemistry
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7841069/
https://ncbi.nlm.nih.gov/pubmed/33520939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2020.624678
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