Identification of Chalcone Derivatives as Inhibitors of Leishmania infantum Arginase and Promising Antileishmanial Agents

Arginase catalyzes the hydrolysis of l-arginine into l-ornithine and urea, acting as a key enzyme in the biosynthesis of polyamines. Leishmania growth and survival is dependent on polyamine biosynthesis; therefore, inhibition of Leishmania arginase may be a promising therapeutic strategy. Here, we e...

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Bibliographic Details
Published in:Front Chem
Main Authors: Garcia, Andreza R., Oliveira, Danielle M. P., Jesus, Jessica B., Souza, Alessandra M. T., Sodero, Ana Carolina R., Vermelho, Alane B., Leal, Ivana C. R., Souza, Rodrigo Octavio M. A., Miranda, Leandro S. M., Pinheiro, Anderson S., Rodrigues, Igor A.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2021
Subjects:
Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7841069/
https://ncbi.nlm.nih.gov/pubmed/33520939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2020.624678
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