Identification of Chalcone Derivatives as Inhibitors of Leishmania infantum Arginase and Promising Antileishmanial Agents

Arginase catalyzes the hydrolysis of l-arginine into l-ornithine and urea, acting as a key enzyme in the biosynthesis of polyamines. Leishmania growth and survival is dependent on polyamine biosynthesis; therefore, inhibition of Leishmania arginase may be a promising therapeutic strategy. Here, we e...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Chem
Prif Awduron: Garcia, Andreza R., Oliveira, Danielle M. P., Jesus, Jessica B., Souza, Alessandra M. T., Sodero, Ana Carolina R., Vermelho, Alane B., Leal, Ivana C. R., Souza, Rodrigo Octavio M. A., Miranda, Leandro S. M., Pinheiro, Anderson S., Rodrigues, Igor A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2021
Pynciau:
Chemistry
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7841069/
https://ncbi.nlm.nih.gov/pubmed/33520939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2020.624678
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