Identification of Chalcone Derivatives as Inhibitors of Leishmania infantum Arginase and Promising Antileishmanial Agents

Arginase catalyzes the hydrolysis of l-arginine into l-ornithine and urea, acting as a key enzyme in the biosynthesis of polyamines. Leishmania growth and survival is dependent on polyamine biosynthesis; therefore, inhibition of Leishmania arginase may be a promising therapeutic strategy. Here, we e...

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Bibliografske podrobnosti
izdano v:Front Chem
Main Authors: Garcia, Andreza R., Oliveira, Danielle M. P., Jesus, Jessica B., Souza, Alessandra M. T., Sodero, Ana Carolina R., Vermelho, Alane B., Leal, Ivana C. R., Souza, Rodrigo Octavio M. A., Miranda, Leandro S. M., Pinheiro, Anderson S., Rodrigues, Igor A.
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2021
Teme:
Chemistry
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7841069/
https://ncbi.nlm.nih.gov/pubmed/33520939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2020.624678
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