GSK3 Inhibits Macropinocytosis and Lysosomal Activity through the Wnt Destruction Complex Machinery

Canonical Wnt signaling is emerging as a major regulator of endocytosis. Here, we report that Wnt-induced macropinocytosis is regulated through glycogen synthase kinase 3 (GSK3) and the β-catenin destruction complex. We find that mutation of Axin1, a tumor suppressor and component of the destruction...

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Udgivet i:Cell Rep
Main Authors: Albrecht, Lauren V., Tejeda-Muñoz, Nydia, Bui, Maggie H., Cicchetto, Andrew C., Di Biagio, Daniele, Colozza, Gabriele, Schmid, Ernst, Piccolo, Stefano, Christofk, Heather R., De Robertis, Edward M.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7666578/
https://ncbi.nlm.nih.gov/pubmed/32726636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.107973
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