Presenilin Deficiency or Lysosomal Inhibition Enhance Wnt Signaling Through Relocalization of GSK3 to the Late Endosomal Compartment

Sustained canonical Wnt signaling requires inhibition of Glycogen Synthase Kinase 3 (GSK3) activity through its sequestration inside multivesicular endosomes (MVEs). Here we show that Wnt signaling is increased by the lysosomal inhibitor Chloroquine, which causes accumulation of MVEs. A similar MVE...

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Detalhes bibliográficos
Main Authors: Dobrowolski, Radek, Vick, Philipp, Ploper, Diego, Gumper, Iwona, Snitkin, Harriet, Sabatini, David D., De Robertis, Edward M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538832/
https://ncbi.nlm.nih.gov/pubmed/23122960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2012.09.026
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