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Presenilin Deficiency or Lysosomal Inhibition Enhance Wnt Signaling Through Relocalization of GSK3 to the Late Endosomal Compartment
Sustained canonical Wnt signaling requires inhibition of Glycogen Synthase Kinase 3 (GSK3) activity through its sequestration inside multivesicular endosomes (MVEs). Here we show that Wnt signaling is increased by the lysosomal inhibitor Chloroquine, which causes accumulation of MVEs. A similar MVE...
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| Asıl Yazarlar: | , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2012
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3538832/ https://ncbi.nlm.nih.gov/pubmed/23122960 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2012.09.026 |
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