Wnt Signaling Requires the Sequestration of Glycogen Synthase Kinase 3 inside Multivesicular Endosomes

Canonical Wnt signaling requires inhibition of Glycogen Synthase Kinase 3 (GSK3) activity, but the molecular mechanism by which this is achieved remains unclear. Here we report that Wnt signaling triggers the sequestration of GSK3 from the cytosol into multivesicular bodies (MVBs), so that this enzy...

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Hlavní autoři: Taelman, Vincent F., Dobrowolski, Radoslaw, Plouhinec, Jean-Louis, Fuentealba, Luis C., Vorwald, Peggy P., Gumper, Iwona, Sabatini, David D., De Robertis, Edward M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3022472/
https://ncbi.nlm.nih.gov/pubmed/21183076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.11.034
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