Wnt Signaling Requires the Sequestration of Glycogen Synthase Kinase 3 inside Multivesicular Endosomes

Canonical Wnt signaling requires inhibition of Glycogen Synthase Kinase 3 (GSK3) activity, but the molecular mechanism by which this is achieved remains unclear. Here we report that Wnt signaling triggers the sequestration of GSK3 from the cytosol into multivesicular bodies (MVBs), so that this enzy...

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Bibliografski detalji
Glavni autori: Taelman, Vincent F., Dobrowolski, Radoslaw, Plouhinec, Jean-Louis, Fuentealba, Luis C., Vorwald, Peggy P., Gumper, Iwona, Sabatini, David D., De Robertis, Edward M.
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3022472/
https://ncbi.nlm.nih.gov/pubmed/21183076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.11.034
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