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Canonical Wnt is inhibited by targeting one-carbon metabolism through methotrexate or methionine deprivation
The nutrient-sensing metabolite S-adenosylmethionine (SAM) controls one-carbon metabolism by donating methyl groups to biochemical building blocks, DNA, RNA, and protein. Our recent work uncovered a requirement for cytoplasmic arginine methylation during Wnt signaling through the activity of protein...
Tallennettuna:
| Julkaisussa: | Proc Natl Acad Sci U S A |
|---|---|
| Päätekijät: | , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
National Academy of Sciences
2019
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6386671/ https://ncbi.nlm.nih.gov/pubmed/30679275 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1820161116 |
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