Frequency and methylation status of selected retrotransposition competent L1 loci in amyotrophic lateral sclerosis

Long interspersed element-1 (LINE-1/L1) is the only autonomous transposable element in the human genome that currently mobilises in both germline and somatic tissues. Recent studies have identified correlations between altered retrotransposon expression and the fatal neurodegenerative disease amyotr...

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Veröffentlicht in:Mol Brain
Hauptverfasser: Savage, Abigail L., Lopez, Ana Illera, Iacoangeli, Alfredo, Bubb, Vivien J., Smith, Bradley, Troakes, Claire, Alahmady, Nada, Koks, Sulev, Schumann, Gerald G., Al-Chalabi, Ammar, Quinn, John P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7666467/
https://ncbi.nlm.nih.gov/pubmed/33187550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-020-00694-2
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