Sapap3 deletion causes dynamic synaptic density abnormalities: a longitudinal [(11)C]UCB-J PET study in a model of obsessive–compulsive disorder-like behaviour

BACKGROUND: Currently, the evidence on synaptic abnormalities in neuropsychiatric disorders—including obsessive–compulsive disorder (OCD)—is emerging. The newly established positron emission tomography (PET) ligand ((R)-1-((3-((11)C-methyl-(11)C)pyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolid...

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Detalhes bibliográficos
Publicado no:EJNMMI Res
Main Authors: Glorie, Dorien, Verhaeghe, Jeroen, Miranda, Alan, De Lombaerde, Stef, Stroobants, Sigrid, Staelens, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2020
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7666267/
https://ncbi.nlm.nih.gov/pubmed/33185747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13550-020-00721-2
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