YTHDC1 mitigates ischemic stroke by promoting Akt phosphorylation through destabilizing PTEN mRNA

YTH Domain Containing 1 (YTHDC1) is one of the m(6)A readers that is essential for oocyte development and tumor progression. The role of YTHDC1 in neuronal survival and ischemic stroke is unknown. Here, we found that YTHDC1 was unregulated in the early phase of ischemic stroke. Knockdown of YTHDC1 e...

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Pubblicato in:Cell Death Dis
Autori principali: Zhang, Zhaolong, Wang, Qiuhan, Zhao, Xiaolong, Shao, Liming, Liu, Guoping, Zheng, Xuan, Xie, Lingling, Zhang, Yan, Sun, Chengjian, Xu, Rui
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7666223/
https://ncbi.nlm.nih.gov/pubmed/33188203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03186-2
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