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Leflunomide triggers synthetic lethality in PTEN-deficient prostate cancer
BACKGROUND: The loss of PTEN function presents in up to 50% of late-stage prostate cancers, and is therefore a potential target for therapeutics. PTEN-deficient cells depend on de novo pyrimidine synthesis, a feature which can present a vulnerability. METHODS: We utilized in vitro growth assays and...
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| Publicado no: | Prostate Cancer Prostatic Dis |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7666085/ https://ncbi.nlm.nih.gov/pubmed/32661432 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41391-020-0251-1 |
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