Loading...

Chromatin remodeling ATPase BRG1 and PTEN are synthetic lethal in prostate cancer

Loss of phosphatase and tensin homolog (PTEN) represents one hallmark of prostate cancer (PCa). However, restoration of PTEN or inhibition of the activated PI3K/AKT pathway has shown limited success, prompting us to identify obligate targets for disease intervention. We hypothesized that PTEN loss m...

Full description

Saved in:
Bibliographic Details
Published in:J Clin Invest
Main Authors: Ding, Yufeng, Li, Ni, Dong, Baijun, Guo, Wangxin, Wei, Hui, Chen, Qilong, Yuan, Huairui, Han, Ying, Chang, Hanwen, Kan, Shan, Wang, Xuege, Pan, Qiang, Wu, Ping, Peng, Chao, Qiu, Tong, Li, Qintong, Gao, Dong, Xue, Wei, Qin, Jun
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355211/
https://ncbi.nlm.nih.gov/pubmed/30496141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI123557
Tags: Add Tag
No Tags, Be the first to tag this record!