Chromatin remodeling ATPase BRG1 and PTEN are synthetic lethal in prostate cancer

Loss of phosphatase and tensin homolog (PTEN) represents one hallmark of prostate cancer (PCa). However, restoration of PTEN or inhibition of the activated PI3K/AKT pathway has shown limited success, prompting us to identify obligate targets for disease intervention. We hypothesized that PTEN loss m...

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Publicat a:J Clin Invest
Autors principals: Ding, Yufeng, Li, Ni, Dong, Baijun, Guo, Wangxin, Wei, Hui, Chen, Qilong, Yuan, Huairui, Han, Ying, Chang, Hanwen, Kan, Shan, Wang, Xuege, Pan, Qiang, Wu, Ping, Peng, Chao, Qiu, Tong, Li, Qintong, Gao, Dong, Xue, Wei, Qin, Jun
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355211/
https://ncbi.nlm.nih.gov/pubmed/30496141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI123557
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