Chromatin remodeling ATPase BRG1 and PTEN are synthetic lethal in prostate cancer

Loss of phosphatase and tensin homolog (PTEN) represents one hallmark of prostate cancer (PCa). However, restoration of PTEN or inhibition of the activated PI3K/AKT pathway has shown limited success, prompting us to identify obligate targets for disease intervention. We hypothesized that PTEN loss m...

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書目詳細資料
發表在:J Clin Invest
Main Authors: Ding, Yufeng, Li, Ni, Dong, Baijun, Guo, Wangxin, Wei, Hui, Chen, Qilong, Yuan, Huairui, Han, Ying, Chang, Hanwen, Kan, Shan, Wang, Xuege, Pan, Qiang, Wu, Ping, Peng, Chao, Qiu, Tong, Li, Qintong, Gao, Dong, Xue, Wei, Qin, Jun
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2019
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355211/
https://ncbi.nlm.nih.gov/pubmed/30496141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI123557
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