Chromatin remodeling ATPase BRG1 and PTEN are synthetic lethal in prostate cancer

Loss of phosphatase and tensin homolog (PTEN) represents one hallmark of prostate cancer (PCa). However, restoration of PTEN or inhibition of the activated PI3K/AKT pathway has shown limited success, prompting us to identify obligate targets for disease intervention. We hypothesized that PTEN loss m...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Ding, Yufeng, Li, Ni, Dong, Baijun, Guo, Wangxin, Wei, Hui, Chen, Qilong, Yuan, Huairui, Han, Ying, Chang, Hanwen, Kan, Shan, Wang, Xuege, Pan, Qiang, Wu, Ping, Peng, Chao, Qiu, Tong, Li, Qintong, Gao, Dong, Xue, Wei, Qin, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355211/
https://ncbi.nlm.nih.gov/pubmed/30496141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI123557
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