The prefoldin complex stabilizes the von Hippel-Lindau protein against aggregation and degradation

Loss of von Hippel-Lindau protein pVHL function promotes VHL diseases, including sporadic and inherited clear cell Renal Cell Carcinoma (ccRCC). Mechanisms controlling pVHL function and regulation, including folding and stability, remain elusive. Here, we have identified the conserved cochaperone pr...

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發表在:PLoS Genet
Main Authors: Chesnel, Franck, Couturier, Anne, Alusse, Adrien, Gagné, Jean-Philippe, Poirier, Guy G., Jean, Dominique, Boisvert, François-Michel, Hascoet, Pauline, Paillard, Luc, Arlot-Bonnemains, Yannick, Le Goff, Xavier
格式: Artigo
語言:Inglês
出版: Public Library of Science 2020
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7660911/
https://ncbi.nlm.nih.gov/pubmed/33137104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009183
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