The prefoldin complex stabilizes the von Hippel-Lindau protein against aggregation and degradation

Loss of von Hippel-Lindau protein pVHL function promotes VHL diseases, including sporadic and inherited clear cell Renal Cell Carcinoma (ccRCC). Mechanisms controlling pVHL function and regulation, including folding and stability, remain elusive. Here, we have identified the conserved cochaperone pr...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Chesnel, Franck, Couturier, Anne, Alusse, Adrien, Gagné, Jean-Philippe, Poirier, Guy G., Jean, Dominique, Boisvert, François-Michel, Hascoet, Pauline, Paillard, Luc, Arlot-Bonnemains, Yannick, Le Goff, Xavier
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7660911/
https://ncbi.nlm.nih.gov/pubmed/33137104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009183
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