The prefoldin complex stabilizes the von Hippel-Lindau protein against aggregation and degradation

Loss of von Hippel-Lindau protein pVHL function promotes VHL diseases, including sporadic and inherited clear cell Renal Cell Carcinoma (ccRCC). Mechanisms controlling pVHL function and regulation, including folding and stability, remain elusive. Here, we have identified the conserved cochaperone pr...

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Bibliografische gegevens
Gepubliceerd in:PLoS Genet
Hoofdauteurs: Chesnel, Franck, Couturier, Anne, Alusse, Adrien, Gagné, Jean-Philippe, Poirier, Guy G., Jean, Dominique, Boisvert, François-Michel, Hascoet, Pauline, Paillard, Luc, Arlot-Bonnemains, Yannick, Le Goff, Xavier
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2020
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7660911/
https://ncbi.nlm.nih.gov/pubmed/33137104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009183
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