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In vivo miRNA knockout screening identifies miR-190b as a novel tumor suppressor

MicroRNAs (miRNAs) play important roles in the development of various cancers including lung cancer which is one of the devastating diseases worldwide. How miRNAs function in de novo lung tumorigenesis remains largely unknown. We here developed a CRISPR/Cas9-mediated dual guide RNA (dgRNA) system to...

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書目詳細資料
發表在:PLoS Genet
Main Authors: Hong, Hui, Yao, Shun, Zhang, Yuanyuan, Ye, Yi, Li, Cheng, Hu, Liang, Sun, Yihua, Huang, Hsin-Yi, Ji, Hongbin
格式: Artigo
語言:Inglês
出版: Public Library of Science 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7660552/
https://ncbi.nlm.nih.gov/pubmed/33137086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009168
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