In vivo miRNA knockout screening identifies miR-190b as a novel tumor suppressor

MicroRNAs (miRNAs) play important roles in the development of various cancers including lung cancer which is one of the devastating diseases worldwide. How miRNAs function in de novo lung tumorigenesis remains largely unknown. We here developed a CRISPR/Cas9-mediated dual guide RNA (dgRNA) system to...

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Publicat a:PLoS Genet
Autors principals: Hong, Hui, Yao, Shun, Zhang, Yuanyuan, Ye, Yi, Li, Cheng, Hu, Liang, Sun, Yihua, Huang, Hsin-Yi, Ji, Hongbin
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7660552/
https://ncbi.nlm.nih.gov/pubmed/33137086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009168
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