In vivo miRNA knockout screening identifies miR-190b as a novel tumor suppressor

MicroRNAs (miRNAs) play important roles in the development of various cancers including lung cancer which is one of the devastating diseases worldwide. How miRNAs function in de novo lung tumorigenesis remains largely unknown. We here developed a CRISPR/Cas9-mediated dual guide RNA (dgRNA) system to...

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Gepubliceerd in:PLoS Genet
Hoofdauteurs: Hong, Hui, Yao, Shun, Zhang, Yuanyuan, Ye, Yi, Li, Cheng, Hu, Liang, Sun, Yihua, Huang, Hsin-Yi, Ji, Hongbin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2020
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7660552/
https://ncbi.nlm.nih.gov/pubmed/33137086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009168
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