TRPV4 antagonism prevents mechanically-induced myotonia

OBJECTIVE: Myotonia is caused by involuntary firing of skeletal muscle action potentials and causes debilitating stiffness. Current treatments are insufficiently efficacious and associated with side effects. Myotonia can be triggered by voluntary movement (electrically-induced myotonia) or percussio...

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Detalhes bibliográficos
Publicado no:Ann Neurol
Main Authors: Dupont, Chris, Novak, Kevin, Denman, Kirsten, Myers, Jessica H., Sullivan, Jeremy M., Walker, Phillip V, Brown, Nicklaus L., Ladle, David R., Bogdanik, Laurent, Lutz, Cathleen M., Voss, Andrew, Sumner, Charlotte J., Rich, Mark M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7657963/
https://ncbi.nlm.nih.gov/pubmed/32418267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.25780
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