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Inhibiting persistent inward sodium currents prevents myotonia
OBJECTIVE: Patients with myotonia congenita have muscle hyperexcitability due to loss‐of‐function mutations in the ClC‐1 chloride channel in skeletal muscle, which causes involuntary firing of muscle action potentials (myotonia), producing muscle stiffness. The excitatory events that trigger myotoni...
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| Publicado no: | Ann Neurol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5639374/ https://ncbi.nlm.nih.gov/pubmed/28833464 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.25017 |
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