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The Role of Kv7.2 in Neurodevelopment: Insights and Gaps in Our Understanding

Kv7.2 subunits encoded by the KCNQ2 gene constitute a critical molecular component of the M-current, a subthreshold voltage-gated potassium current controlling neuronal excitability by dampening repetitive action potential firing. Pathogenic loss-of-function variants in KCNQ2 have been linked to epi...

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Vydáno v:Front Physiol
Hlavní autoři: Dirkx, Nina, Miceli, Francesco, Taglialatela, Maurizio, Weckhuysen, Sarah
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7657400/
https://ncbi.nlm.nih.gov/pubmed/33192566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2020.570588
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