Early-onset epileptic encephalopathy caused by a reduced sensitivity of Kv7.2 potassium channels to phosphatidylinositol 4,5-bisphosphate

Kv7.2 and Kv7.3 subunits underlie the M-current, a neuronal K(+) current characterized by an absolute functional requirement for phosphatidylinositol 4,5-bisphosphate (PIP(2)). Kv7.2 gene mutations cause early-onset neonatal seizures with heterogeneous clinical outcomes, ranging from self-limiting b...

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Publicado en:Sci Rep
Main Authors: Soldovieri, Maria Virginia, Ambrosino, Paolo, Mosca, Ilaria, De Maria, Michela, Moretto, Edoardo, Miceli, Francesco, Alaimo, Alessandro, Iraci, Nunzio, Manocchio, Laura, Medoro, Alessandro, Passafaro, Maria, Taglialatela, Maurizio
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5131271/
https://ncbi.nlm.nih.gov/pubmed/27905566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep38167
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