Novel leukemic cell lines resistant to clofarabine by mechanisms of decreased active metabolite and increased antiapoptosis

Clofarabine (CAFdA) is incorporated into leukemic cells by human equilibrative nucleoside transporters (hENT) 1 and 2 and human concentrative nucleoside transporter (hCNT) 3. CAFdA is then phosphorylated to the active metabolite CAFdA triphosphate (CAFdATP) by deoxycytidine kinase (dCK) and deoxygua...

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Bibliographic Details
Published in:Cancer Sci
Main Authors: Shigemi, Hiroko, Yamauchi, Takahiro, Tanaka, Yukie, Ueda, Takanori
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2013
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7657150/
https://ncbi.nlm.nih.gov/pubmed/23421409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12131
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