CrrB Positively Regulates High-Level Polymyxin Resistance and Virulence in Klebsiella pneumoniae

Polymyxin resistance (PR) threatens the treatment of carbapenem-resistant Klebsiella pneumoniae (CRKP) infections. PR frequently arises through chemical modification of the lipid A portion of lipopolysaccharide. Various mutations are implicated in PR, including in three two-component systems—CrrA/B,...

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Udgivet i:Cell Rep
Main Authors: McConville, Thomas H., Annavajhala, Medini K., Giddins, Marla J., Macesic, Nenad, Herrera, Carmen M., Rozenberg, Felix D., Bhushan, Gitanjali L., Ahn, Danielle, Mancia, Filippo, Trent, M. Stephen, Uhlemann, Anne-Catrin
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7656232/
https://ncbi.nlm.nih.gov/pubmed/33113377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108313
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