Emergence of Polymyxin Resistance in Clinical Klebsiella pneumoniae Through Diverse Genetic Adaptations: A Genomic, Retrospective Cohort Study

BACKGROUND: Polymyxins are antimicrobials of last resort for the treatment of carbapenem-resistant Enterobacteriaceae, but resistance in 5% to >40% isolates has been reported. We conducted a genomic survey of clinical polymyxin-resistant (PR) Klebsiella pneumoniae to determine the molecular mecha...

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Detalhes bibliográficos
Publicado no:Clin Infect Dis
Main Authors: Macesic, Nenad, Nelson, Brian, Mcconville, Thomas H, Giddins, Marla J, Green, Daniel A, Stump, Stephania, Gomez-Simmonds, Angela, Annavajhala, Medini K, Uhlemann, Anne-Catrin
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
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Articles and Commentaries
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7201408/
https://ncbi.nlm.nih.gov/pubmed/31513705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/ciz623
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