Phosphodiesterase PDE4D Is Decreased in Frontal Cortex of Aged Rats and Positively Correlated With Working Memory Performance and Inversely Correlated With PKA Phosphorylation of Tau

Age is the largest risk factor for Alzheimer’s disease (AD) and contributes to cognitive impairment in otherwise healthy individuals. Thus, it is critical that we better understand the risk aging presents to vulnerable regions of the brain and carefully design therapeutics to address those effects....

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Detalles Bibliográficos
Publicado en:Front Aging Neurosci
Main Authors: Leslie, Shannon N., Datta, Dibyadeep, Christensen, Kyle R., van Dyck, Christopher H., Arnsten, Amy F. T., Nairn, Angus C.
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2020
Assuntos:
Neuroscience
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7655962/
https://ncbi.nlm.nih.gov/pubmed/33192469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2020.576723
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