Phosphodiesterase PDE4D Is Decreased in Frontal Cortex of Aged Rats and Positively Correlated With Working Memory Performance and Inversely Correlated With PKA Phosphorylation of Tau

Age is the largest risk factor for Alzheimer’s disease (AD) and contributes to cognitive impairment in otherwise healthy individuals. Thus, it is critical that we better understand the risk aging presents to vulnerable regions of the brain and carefully design therapeutics to address those effects....

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Опубликовано в: :Front Aging Neurosci
Главные авторы: Leslie, Shannon N., Datta, Dibyadeep, Christensen, Kyle R., van Dyck, Christopher H., Arnsten, Amy F. T., Nairn, Angus C.
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2020
Предметы:
Neuroscience
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7655962/
https://ncbi.nlm.nih.gov/pubmed/33192469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2020.576723
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