Chronic copper exposure directs microglia towards degenerative expression signatures in wild-type and J20 mouse model of Alzheimer’s disease

BACKGROUND: Copper (Cu) is an essential metal mediating a variety of vital biological reactions with its redox property. Its dyshomeostasis has been associated with accelerated cognitive decline and neurodegenerative disorders, such as Alzheimer’s disease (AD). However, underlying neurotoxic mechani...

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Detalhes bibliográficos
Publicado no:J Trace Elem Med Biol
Main Authors: Lim, Siok Lam, Rodriguez-Ortiz, Carlos J., Hsu, Heng-Wei, Wu, Jie, Zumkehr, Joannee, Kilian, Jason, Vidal, Janielle, Ayata, Pinar, Kitazawa, Masashi
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7655674/
https://ncbi.nlm.nih.gov/pubmed/32599538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtemb.2020.126578
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