Distinct pharmacological profiles of ORAI1, ORAI2, and ORAI3 channels

The ubiquitous Ca(2+) release-activated Ca(2+) (CRAC) channel is crucial to many physiological functions. Both gain and loss of CRAC function is linked to disease. While ORAI1 is a crucial subunit of CRAC channels, recent evidence suggests that ORAI2 and ORAI3 heteromerize with ORAI1 to form native...

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Bibliographic Details
Published in:Cell Calcium
Main Authors: Zhang, Xuexin, Xin, Ping, Yoast, Ryan E., Emrich, Scott M., Johnson, Martin T., Pathak, Trayambak, Benson, J. Cory, Azimi, Iman, Gill, Donald L., Monteith, Gregory R., Trebak, Mohamed
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7654283/
https://ncbi.nlm.nih.gov/pubmed/32896813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ceca.2020.102281
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