A New Selective Pharmacological Enhancer of the Orai1 Ca(2+) Channel Reveals Roles for Orai1 in Smooth and Skeletal Muscle Functions

[Image: see text] Store-operated calcium (Ca(2+)) entry is an important homeostatic mechanism in cells, whereby the release of Ca(2+) from intracellular endoplasmic reticulum stores triggers the activation of a Ca(2+) influx pathway. Mediated by Orai1, this Ca(2+) influx has specific and essential r...

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Publicado no:ACS Pharmacol Transl Sci
Main Authors: Azimi, Iman, Stevenson, Ralph J., Zhang, Xuexin, Meizoso-Huesca, Aldo, Xin, Ping, Johnson, Martin, Flanagan, Jack U., Chalmers, Silke B., Yoast, Ryan E., Kapure, Jeevak S., Ross, Benjamin P., Vetter, Irina, Ashton, Mark R., Launikonis, Bradley S., Denny, William A., Trebak, Mohamed, Monteith, Gregory R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7079732/
https://ncbi.nlm.nih.gov/pubmed/32190822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.9b00081
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