A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction

ORAI1 constitutes the store-operated Ca(2+) release-activated Ca(2+) (CRAC) channel crucial for life. Whereas ORAI1 activation by Ca(2+)-sensing STIM proteins is known, still obscure is how ORAI1 is turned off through Ca(2+)-dependent inactivation (CDI), protecting against Ca(2+) toxicity. Here we i...

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Publicado no:Nat Commun
Main Authors: Zhang, Xuexin, Pathak, Trayambak, Yoast, Ryan, Emrich, Scott, Xin, Ping, Nwokonko, Robert M., Johnson, Martin, Wu, Shilan, Delierneux, Céline, Gueguinou, Maxime, Hempel, Nadine, Putney, James W., Gill, Donald L., Trebak, Mohamed
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6488650/
https://ncbi.nlm.nih.gov/pubmed/31036819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09593-0
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