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A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction
ORAI1 constitutes the store-operated Ca(2+) release-activated Ca(2+) (CRAC) channel crucial for life. Whereas ORAI1 activation by Ca(2+)-sensing STIM proteins is known, still obscure is how ORAI1 is turned off through Ca(2+)-dependent inactivation (CDI), protecting against Ca(2+) toxicity. Here we i...
שמור ב:
הוצא לאור ב: | Nat Commun |
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Main Authors: | , , , , , , , , , , , , , |
פורמט: | Artigo |
שפה: | Inglês |
יצא לאור: |
Nature Publishing Group UK
2019
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נושאים: | |
גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6488650/ https://ncbi.nlm.nih.gov/pubmed/31036819 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09593-0 |
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