Genetic and epigenetic landscape of IDH-wildtype glioblastomas with FGFR3-TACC3 fusions

A subset of glioblastomas (GBMs) harbors potentially druggable oncogenic FGFR3-TACC3 (F3T3) fusions. However, their associated molecular and clinical features are poorly understood. Here we analyze the frequency of F3T3-fusion positivity, its associated genetic and methylation profiles, and its impa...

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Dettagli Bibliografici
Pubblicato in:Acta Neuropathol Commun
Autori principali: Mata, Douglas A., Benhamida, Jamal K., Lin, Andrew L., Vanderbilt, Chad M., Yang, Soo-Ryum, Villafania, Liliana B., Ferguson, Donna C., Jonsson, Philip, Miller, Alexandra M., Tabar, Viviane, Brennan, Cameron W., Moss, Nelson S., Sill, Martin, Benayed, Ryma, Mellinghoff, Ingo K., Rosenblum, Marc K., Arcila, Maria E., Ladanyi, Marc, Bale, Tejus A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2020
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7653727/
https://ncbi.nlm.nih.gov/pubmed/33168106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-01058-6
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