The efficiency of insulin production and its content in insulin-expressing model β-cells correlate with their Zn(2+) levels

Insulin is produced and stored inside the pancreatic β-cell secretory granules, where it is assumed to form Zn(2+)-stabilized oligomers. However, the actual storage forms of this hormone and the impact of zinc ions on insulin production in vivo are not known. Our initial X-ray fluorescence experimen...

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Veröffentlicht in:Open Biol
Hauptverfasser: Dzianová, Petra, Asai, Seiya, Chrudinová, Martina, Kosinová, Lucie, Potalitsyn, Pavlo, Šácha, Pavel, Hadravová, Romana, Selicharová, Irena, Kříž, Jan, Turkenburg, Johan P., Brzozowski, Andrzej Marek, Jiráček, Jiří, Žáková, Lenka
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Royal Society 2020
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7653362/
https://ncbi.nlm.nih.gov/pubmed/33081637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.200137
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