A versatile insulin analog with high potency for both insulin and insulin-like growth factor 1 receptors: Structural implications for receptor binding

Insulin and insulin-like growth factor 1 (IGF-1) are closely related hormones involved in the regulation of metabolism and growth. They elicit their functions through activation of tyrosine kinase–type receptors: insulin receptors (IR-A and IR-B) and IGF-1 receptor (IGF-1R). Despite similarity in pr...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Chrudinová, Martina, Žáková, Lenka, Marek, Aleš, Socha, Ondřej, Buděšínský, Miloš, Hubálek, Martin, Pícha, Jan, Macháčková, Kateřina, Jiráček, Jiří, Selicharová, Irena
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2018
Soggetti:
Protein Structure and Folding
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6204900/
https://ncbi.nlm.nih.gov/pubmed/30213860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004852
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