Mitochondrial DNA Mutation Analysis in Breast Cancer: Shifting From Germline Heteroplasmy Toward Homoplasmy in Tumors

Studies have suggested a potential role of somatic mitochondrial mutations in cancer development. To analyze the landscape of somatic mitochondrial mutation in breast cancer and to determine whether mitochondrial DNA (mtDNA) mutational burden is correlated with overall survival (OS), we sequenced wh...

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Bibliografske podrobnosti
izdano v:Front Oncol
Main Authors: Pérez-Amado, Carlos Jhovani, Tovar, Hugo, Gómez-Romero, Laura, Beltrán-Anaya, Fredy Omar, Bautista-Piña, Verónica, Dominguez-Reyes, Carlos, Villegas-Carlos, Felipe, Tenorio-Torres, Alberto, Alfaro-Ruíz, Luis Alberto, Hidalgo-Miranda, Alfredo, Jiménez-Morales, Silvia
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2020
Teme:
Oncology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7653098/
https://ncbi.nlm.nih.gov/pubmed/33194675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.572954
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