Mitochondrial DNA Mutation Analysis in Breast Cancer: Shifting From Germline Heteroplasmy Toward Homoplasmy in Tumors

Studies have suggested a potential role of somatic mitochondrial mutations in cancer development. To analyze the landscape of somatic mitochondrial mutation in breast cancer and to determine whether mitochondrial DNA (mtDNA) mutational burden is correlated with overall survival (OS), we sequenced wh...

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Detalles Bibliográficos
Publicado en:Front Oncol
Autores principales: Pérez-Amado, Carlos Jhovani, Tovar, Hugo, Gómez-Romero, Laura, Beltrán-Anaya, Fredy Omar, Bautista-Piña, Verónica, Dominguez-Reyes, Carlos, Villegas-Carlos, Felipe, Tenorio-Torres, Alberto, Alfaro-Ruíz, Luis Alberto, Hidalgo-Miranda, Alfredo, Jiménez-Morales, Silvia
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7653098/
https://ncbi.nlm.nih.gov/pubmed/33194675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.572954
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