Mitochondrial DNA Mutation Analysis in Breast Cancer: Shifting From Germline Heteroplasmy Toward Homoplasmy in Tumors

Studies have suggested a potential role of somatic mitochondrial mutations in cancer development. To analyze the landscape of somatic mitochondrial mutation in breast cancer and to determine whether mitochondrial DNA (mtDNA) mutational burden is correlated with overall survival (OS), we sequenced wh...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Pérez-Amado, Carlos Jhovani, Tovar, Hugo, Gómez-Romero, Laura, Beltrán-Anaya, Fredy Omar, Bautista-Piña, Verónica, Dominguez-Reyes, Carlos, Villegas-Carlos, Felipe, Tenorio-Torres, Alberto, Alfaro-Ruíz, Luis Alberto, Hidalgo-Miranda, Alfredo, Jiménez-Morales, Silvia
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7653098/
https://ncbi.nlm.nih.gov/pubmed/33194675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.572954
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