Mitochondrial DNA Mutation Analysis in Breast Cancer: Shifting From Germline Heteroplasmy Toward Homoplasmy in Tumors

Studies have suggested a potential role of somatic mitochondrial mutations in cancer development. To analyze the landscape of somatic mitochondrial mutation in breast cancer and to determine whether mitochondrial DNA (mtDNA) mutational burden is correlated with overall survival (OS), we sequenced wh...

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Vydáno v:Front Oncol
Hlavní autoři: Pérez-Amado, Carlos Jhovani, Tovar, Hugo, Gómez-Romero, Laura, Beltrán-Anaya, Fredy Omar, Bautista-Piña, Verónica, Dominguez-Reyes, Carlos, Villegas-Carlos, Felipe, Tenorio-Torres, Alberto, Alfaro-Ruíz, Luis Alberto, Hidalgo-Miranda, Alfredo, Jiménez-Morales, Silvia
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Oncology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7653098/
https://ncbi.nlm.nih.gov/pubmed/33194675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.572954
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