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Aberrant autophagosome formation occurs upon small molecule inhibition of ULK1 kinase activity

Autophagy is a crucial homeostatic mechanism that mediates the degradation of damaged or excess intracellular components. Such components are engulfed and sequestered into double membrane autophagosomes, which deliver their contents to lysosomes for degradation. Autophagy plays a role in numerous hu...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Life Sci Alliance
Prif Awduron: Zachari, Maria, Longo, Marianna, Ganley, Ian G
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Life Science Alliance LLC 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7652397/
https://ncbi.nlm.nih.gov/pubmed/33109685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.202000815
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