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Recent progress in the discovery of ghrelin O-acyltransferase (GOAT) inhibitors
Ghrelin is a stomach-derived peptide hormone which stimulates appetite. For ghrelin to exert its orexigenic effect, octanoylation on the serine-3 residue of this gut–brain peptide is essential. The octanoylation of ghrelin is mediated by a unique acyltransferase enzyme known as ghrelin O-acyltransfe...
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| Veröffentlicht in: | RSC Med Chem |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Royal Society of Chemistry
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7651998/ https://ncbi.nlm.nih.gov/pubmed/33479618 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0md00210k |
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