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Recent progress in the discovery of ghrelin O-acyltransferase (GOAT) inhibitors

Ghrelin is a stomach-derived peptide hormone which stimulates appetite. For ghrelin to exert its orexigenic effect, octanoylation on the serine-3 residue of this gut–brain peptide is essential. The octanoylation of ghrelin is mediated by a unique acyltransferase enzyme known as ghrelin O-acyltransfe...

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Vydáno v:RSC Med Chem
Hlavní autoři: Iyer, Malliga R., Wood, Casey M., Kunos, George
Médium: Artigo
Jazyk:Inglês
Vydáno: Royal Society of Chemistry 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651998/
https://ncbi.nlm.nih.gov/pubmed/33479618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0md00210k
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