TAMI-30. LOCAL TARGETING OF NAD(+) SALVAGE PATHWAY ALTERS THE IMMUNE TUMOR MICROENVIRONMENT AND ENHANCES CHECKPOINT IMMUNOTHERAPY IN GLIOBLASTOMA

The aggressive primary brain tumor glioblastoma (GBM) is characterized by aberrant metabolism that fuels its malignant phenotype. Diverse genetic sub-types of malignant glioma are sensitive to selective inhibition of the NAD+ salvage pathway enzyme nicotinamide phosphoribosyltransferase (NAMPT). How...

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Vydáno v:Neuro Oncol
Hlavní autoři: Li, Ming, Kirtane, Ameya, Kiyokawa, Juri, Nagashima, Hiroaki, Traverso, Giovanni, Cahill, Daniel, Wakimoto, Hiroaki
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Tumor Microenvironment/Angiogenesis/Metabolism/Invasion
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651483/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.918
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