TAMI-30. LOCAL TARGETING OF NAD(+) SALVAGE PATHWAY ALTERS THE IMMUNE TUMOR MICROENVIRONMENT AND ENHANCES CHECKPOINT IMMUNOTHERAPY IN GLIOBLASTOMA

The aggressive primary brain tumor glioblastoma (GBM) is characterized by aberrant metabolism that fuels its malignant phenotype. Diverse genetic sub-types of malignant glioma are sensitive to selective inhibition of the NAD+ salvage pathway enzyme nicotinamide phosphoribosyltransferase (NAMPT). How...

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Detalles Bibliográficos
Publicado en:Neuro Oncol
Main Authors: Li, Ming, Kirtane, Ameya, Kiyokawa, Juri, Nagashima, Hiroaki, Traverso, Giovanni, Cahill, Daniel, Wakimoto, Hiroaki
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2020
Assuntos:
Tumor Microenvironment/Angiogenesis/Metabolism/Invasion
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651483/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.918
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