TMOD-23. A NOVEL BRAF V600E LOW-GRADE GLIOMA MOUSE MODEL HIGHLIGHTS EXOMIC AND TUMOR IMMUNE ALTERATIONS AND DIFFERING THERAPEUTIC RESPONSES IN LOW- AND HIGH-GRADE GLIOMAS

Pediatric low-grade glioma (pLGG), the most common brain cancer in children, is difficult to treat especially at recurrence. The BRAF V600E mutation is the second most common mutation in pLGG, and in a high-risk group for progression is associated with deletion of the tumor suppressor CDKN2A. A bett...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Marie Barrette, Anne, Meyer, Lasse, Hirata, Yoko, Grossauer, Stefan, Lu, Edbert, Tamaki, Whitney, Petritsch, Claudia, Wang, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Tumor Models
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651454/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.973
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