TMOD-23. A NOVEL BRAF V600E LOW-GRADE GLIOMA MOUSE MODEL HIGHLIGHTS EXOMIC AND TUMOR IMMUNE ALTERATIONS AND DIFFERING THERAPEUTIC RESPONSES IN LOW- AND HIGH-GRADE GLIOMAS

Pediatric low-grade glioma (pLGG), the most common brain cancer in children, is difficult to treat especially at recurrence. The BRAF V600E mutation is the second most common mutation in pLGG, and in a high-risk group for progression is associated with deletion of the tumor suppressor CDKN2A. A bett...

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Podrobná bibliografie
Vydáno v:Neuro Oncol
Hlavní autoři: Marie Barrette, Anne, Meyer, Lasse, Hirata, Yoko, Grossauer, Stefan, Lu, Edbert, Tamaki, Whitney, Petritsch, Claudia, Wang, Wei
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Tumor Models
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651454/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.973
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