BIOL-05. MAPK PATHWAY INHIBITION SENSITIZES TO IMMUNOTHERAPY IN BRAF-MUTANT GLIOMAS

BACKGROUND: BRAF alterations frequently occur in pediatric low-grade gliomas. Previously, we showed that dabrafenib and trametinib (D+T) that target MAPK pathway can mediate the antitumor effect in a preclinical model of BRAF-mutant glioma (PMC5342782). Here, we further investigate the effect of MAP...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Park, Jong-Whi, Barrette, Anne-Marie, Wang, Wei, Grossauer, Stefan, Grant, Gerald, Lau, Ken, Pitteri, Sharon, Monje, Michelle, Petritsch, Claudia
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2021
Fag:
Basic Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168157/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noab090.012
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