Concurrent MEK targeted therapy prevents MAPK pathway reactivation during BRAF(V600E) targeted inhibition in a novel syngeneic murine glioma model

Inhibitors of BRAF(V600E) kinase are currently under investigations in preclinical and clinical studies involving BRAF(V600E) glioma. Studies demonstrated clinical response to such individualized therapy in the majority of patients whereas in some patients tumors continue to grow despite treatment....

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Veröffentlicht in:Oncotarget
Hauptverfasser: Grossauer, Stefan, Koeck, Katharina, Murphy, Nicole E., Meyers, Ian D., Daynac, Mathieu, Truffaux, Nathalene, Truong, Albert Y., Nicolaides, Theodore P., McMahon, Martin, Berger, Mitchel S., Phillips, Joanna J., James, David C., Petritsch, Claudia K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342782/
https://ncbi.nlm.nih.gov/pubmed/27713119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12419
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